Kengo Nagashima



Curriculum vitae (PDF)

Papers Under Review

  1. Nagashima K, Noma H, Furukawa TA. Prediction interval for random-effects meta-analysis: a confidence distribution approach. Under review.

Publications (Peer-Reviewed)

    Statistical Methodology

  1. Nagashima K, Sato Y. Information criteria for Firth's penalized partial likelihood approach in Cox regression models. Statistics in Medicine 2017;36(21):3422–3436. DOI: 10.1002/sim.7368. [Preprint]
  2. Noma H, Nagashima K. A note on the Mantel–Haenszel estimators when the common effect assumptions are violated. Epidemiologic Methods 2016;5(1):19–35. DOI: 10.1515/em-2015-0004.
  3. Nagashima K, Sato Y, Noma H, Hamada C. An efficient and robust method for analyzing population pharmacokinetic data in genome-wide pharmacogenomic studies: a generalized estimating equation approach. Statistics in Medicine 2013;32(27):4838–4858. DOI: 10.1002/sim.5895. [Postprint]
  4. Nagashima K, Sato Y, Hamada C. A modified maximum contrast method for unequal sample sizes in pharmacogenomic studies. Statistical Applications in Genetics and Molecular Biology 2011;10(1):Article 41. DOI: 10.2202/1544-6115.1560. [Postprint] [Software]
  5. Sato Y, Laird NM, Nagashima K, Kato R, Hamano T, Yafune A, Kaniwa N, Saito Y, Sugiyama E, Kim S-R, Furuse J, Ishii H, Ueno H, Okusaka T, Saijo N, Sawada J-i, Yoshida T. A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies. The Pharmacogenomics Journal 2009;9(2):137–146. DOI: 10.1038/tpj.2008.17.
  6. Clinical Research Methodology

  7. Gosho M, Sato Y, Nagashima K, Takahashi S. Trends in study design and the statistical methods employed in a leading general medicine journal. Journal of Clinical Pharmacy and Therapeutics 2017. In press. DOI: 10.1111/jcpt.12605.
  8. Sato Y, Gosho M, Nagashima K, Takahashi S, Ware JH, Laird NM. Statistical methods in the Journal — an update. New England Journal of Medicine 2017;376(11):1086–1087. DOI: 10.1056/NEJMc1616211. (Correspondence) HOT
  9. Gosho M, Nagashima K, Sato Y. Study designs and statistical analyses for biomarker research. Sensors 2012;12(7):8966–8986. DOI: 10.3390/s120708966. (Review)
  10. Medical Researches

  11. Yanai T, Iwasa S, Hashimoto H, Ohyanagi F, Takiguchi T, Takeda K, Nakao M, Sakai H, Nakayama T, Minato K, Arai T, Suzuki K, Shimada Y, Nagashima K, Terakado H, Yamamoto N. A double-blind randomized phase II dose-finding study of olanzapine 10 mg or 5 mg for the prophylaxis of emesis induced by highly emetogenic cisplatin-based chemotherapy. International Journal of Clinical Oncology 2017. In press.
  12. Sasaki Y, Iwasa S, Okazaki S, Goto M, Kojima Y, Naganuma A, Nagashima K, Nagai Y, Hirano H, Honma Y, Takashima A, Kato K, Hamaguchi T. A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer. Gastric Cancer 2017. In press. DOI: 10.1007/s10120-017-0753-2.
  13. Iizumi S, Takashima A, Narita Y, Tajika M, Muro K, Kawai S, Yasui H, Matsushima T, Takahari D, Nagashima K, Boku N. Efficacy and safety of taxane-monotherapy in advanced gastric cancer refractory to triplet chemotherapy with docetaxel, cisplatin, and S-1: a multicenter retrospective study. Cancer Chemotherapy and Pharmacology 2017;80(3):575–582. DOI: 10.1007/s00280-017-3397-3.
  14. Shiraishi H, Fujiwara Y, Kakuya T, Tsuta K, Motoi N, Miura N, Watabe Y, Watanabe S-i, Noro R, Nagashima K, Huang W, Yamada T, Asamura H, Ohe Y, Honda K. Actinin-4 protein overexpression as a predictive biomarker in adjuvant chemotherapy for resected lung adenocarcinoma. Biomarkers in Medicine 2017;11(9):721–731. DOI: 10.2217/bmm-2017-0150.
  15. Honma Y, Hokamura N, Nagashima K, Sudo K, Shoji H, Iwasa S, Takashima A, Kato K, Hamaguchi T, Boku N, Ito Y, Itami J, Koyanagi K, Igaki H, Tachimori Y. Clinical outcomes of resectable esophageal cancer with supraclavicular lymph node metastases treated with curative intent. Anticancer Research 2017;37(7):3741–3749. DOI: 10.21873/anticanres.11748.
  16. Nishide A, Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Income-related inequalities in access to dental care services in Japan. International Journal of Environmental Research and Public Health 2017;14(5):524. DOI: 10.3390/ijerph14050524.
  17. Shoji H, Heike Y, Tada K, Kitano S, Nishimura T, Shimada Y, Nagashima K, Aoki K, Hiraoka N, Honma Y, Iwasa S, Takashima A, Kato K, Boku N, Honda K, Yamada T, Hamaguchi T. The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy. Oncotarget 2017. In press. DOI: 10.18632/oncotarget.18297.
  18. Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Impact of geographic accessibility on utilization of the annual health check-ups by income level in Japan: A multilevel analysis. PLoS ONE 2017;12(5):e0177091. DOI: 10.1371/journal.pone.0177091.
  19. Nomura K, Kido M, Tanabe A, Nagashima K, Takenoshita S, Ando K. Investigation of optimal weight gain during pregnancy for Japanese Women. Scientific Reports 2017;7(1):2569. DOI: 10.1038/s41598-017-02863-1.
  20. Korematsu S, Nagashima K, Sato Y, Nagao M, Hasegawa S, Nakamura H, Sugiura S, Miura K, Okada K, Fujisawa T. "Spike" in acute asthma exacerbations during enterovirus D68 epidemic in Japan: A nation-wide survey. Allergology International 2017. In press. DOI: 10.1016/j.alit.2017.04.003.
  21. Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Ema R, Amata A, Sakao S, Nagashima K, Tatsumi K, Hiwasa T. Circulating anti-coatomer protein complex subunit epsilon (COPE) autoantibodies as a potential biomarker for cardio- and cerebro-vascular events in patients with obstructive sleep apnea. Journal of Clinical Sleep Medicine 2017;13(3):393–400. DOI: 10.5664/jcsm.6488.
  22. Koshizaka M, Ishikawa K, Ishikawa T, Kobayashi K, Takemoto M, Horikoshi T, Shimousa R, Takahashi S, Nagashima K, Sato Y, Tatsuno I, Terano T, Hashimoto N, Kuribayashi N, Uchida D, Yokote K, on behalf of the PRIME-V Study Investigators. Efficacy and safety of ipragliflozin and metformin for visceral fat reduction in type 2 diabetes patients receiving treatment with dipeptidyl peptidase-4 inhibitors in Japan: A study protocol for a prospective, multicenter, blinded-endpoint phase IV randomized controlled trial (PRIME-V study). BMJ Open 2017;7(5):e015766. DOI: 10.1136/bmjopen-2016-015766.
  23. Nishimura T, Iwasa S, Nagashima K, Okita N, Takashima A, Honma Y, Kato K, Hamaguchi T, Yamada Y, Shimada Y, Boku N. Irinotecan monotherapy as third-line treatment for advanced gastric cancer refractory to fluoropyrimidines, platinum, and taxanes. Gastric Cancer 2017;20(4):655–662. DOI: 10.1007/s10120-016-0670-9.
  24. Yamamoto Y, Yamaguchi S, Sasho T, Fukawa T, Akatsu Y, Akagi R, Yamaguchi T, Takahashi K, Nagashima K, Takahashi K. Quantitative ultrasound elastography can quantify mechanical and histological tendon healing in a rabbit model of achilles tendon transection. Radiology 2017;283(2):408–417. DOI: 10.1148/radiol.2016160695.
  25. Yamaguchi N, Misawa S, Sato Y, Nagashima K, Katayama K, Sekiguchi Y, Iwai Y, Amino H, Suichi T, Yokota T, Nishida Y, Kohara N, Hirata K, Nishiyama K, Yabe I, Kaida K-I, Suzuki N, Nodera H, Tsuji S, Koike H, Kira J-I, Hanaoka H, Kusunoki S, Kuwabara S, JET-GBS Group. A prospective, multi-center, randomized phase II study to evaluate the efficacy and safety of eculizumab in patients with Guillain-Barré syndrome (GBS): Japanese Eculizumab Trial for GBS (JET-GBS). JMIR Research Protocols 2016;5(4):e210. DOI: 10.2196/resprot.6610.
  26. Nishi T, Kitahara H, Fujimoto Y, Nakayama T, Sugimoto K, Nagashima K, Hanaoka H, Kobayashi Y. Efficacy of intravenous nicorandil for fractional flow reserve assessment: Study protocol for a crossover randomised trial. BMJ Open 2016;6(11):e012737. DOI: 10.1136/bmjopen-2016-012737.
  27. Misawa S, Sato Y, Katayama K, Nagashima K, Aoyagi R, Sekiguchi Y, Sobue G, Koike H, Yabe I, Sasaki H, Watanabe O, Takashima H, Nishizawa M, Kawachi I, Kusunoki S, Mitsui Y, Kikuchi S, Nakashima I, Ikeda S-i, Kohara N, Kanda T, Kira J-i, Hanaoka H, Kuwabara S, for the Japanese POEMS Syndrome for Thalidomide (J-POST) Trial Study Group. Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial. The Lancet Neurology 2016;15(11):1129–1137. DOI: 10.1016/S1474-4422(16)30157-0. HOT
  28. Tada K, Kitano S, Shoji H, Nishimura T, Shimada Y, Nagashima K, Aoki K, Hiraoka N, Honma Y, Iwasa S, Okita N, Takashima A, Kato K, Yamada Y, Katayama N, Boku N, Heike Y, Hamaguchi T. Pretreatment immune status correlates with progression-free survival in chemotherapy-treated metastatic colorectal cancer patients. Cancer Immunology Research 2016;4(7):592–599. DOI: 10.1158/2326-6066.CIR-15-0298.
  29. Sasaki Y, Akasu T, Saito N, Kojima H, Matsuda K, Nakamori S, Komori K, Amagai K, Yamaguchi T, Ohue M, Nagashima K, Yamada Y. Prognostic and predictive value of extended RAS mutation and mismatch repair status in stage III colorectal cancer. Cancer Science 2016;107(7):1006–1012. DOI: 10.1111/cas.12950.
  30. Tanemura N, Uyama Y, Nagashima K, Suzuki T, Asahina Y, Kobayashi Y, Iyo M, Yokote K, Hanaoka H. Comparison of drug use between clinical practice and regulatory approval: results in older Japanese patients with rheumatoid arthritis, diabetes, high blood pressure, or depression. Therapeutic Innovation & Regulatory Science 2016;50(6):743–750. DOI: 10.1177/2168479016648731.
  31. Yamaguchi T, Iwasa S, Nagashima K, Ikezawa N, Hamaguchi T, Shoji H, Honma Y, Takashima A, Okita N, Kato K, Yamada Y, Shimada Y. Comparison of panitumumab plus irinotecan and cetuximab plus irinotecan for KRAS wild-type metastatic colorectal cancer. Anticancer Research 2016;36(7):3531–3536. URL: http://ar.iiarjournals.org/content/36/7/3531.
  32. Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Income related inequality of health care access in Japan: A retrospective cohort study. PLoS ONE 2016;11(3):e0151690. DOI: 10.1371/journal.pone.0151690.
  33. Tawada A, Chiba T, Saito T, Ogasawara S, Suzuki E, Ooka Y, Arai M, Kanda T, Shinozaki M, Goto N, Nagashima K, Yokosuka O. Utility of prediction scores for hepatocellular carcinoma in patients with chronic hepatitis B treated with nucleos(t)ide analogues. Oncology 2016;90(4):199–208. DOI: 10.1159/000444392.
  34. Yamamoto Y, Yamaguchi S, Sasho T, Fukawa T, Akatsu Y, Nagashima K, Takahashi K. Quantitative ultrasound elastography with an acoustic coupler for achilles tendon elasticity: measurement repeatability and normative values. Journal of Ultrasound in Medicine 2016;35(1):159–166. DOI: 10.7863/ultra.14.11042.
  35. Naito S, Tanaka J, Nagashima K, Chang B, Hishiki H, Takahashi Y, Oikawa J, Nagasawa K, Shimojo N, Ishiwada N. The impact of heptavalent pneumococcal conjugate vaccine on the incidence of childhood community-acquired pneumonia and bacteriologically confirmed pneumococcal pneumonia in Japan. Epidemiology and Infection 2016;144(3):494–506. DOI: 10.1017/S0950268815001272.
  36. Aoyagi R, Hamada H, Sato Y, Suzuki H, Onouchi Y, Ebata R, Nagashima K, Terauchi M, Terai M, Hanaoka H, Hata A, on behalf of the KAICA Trial investigators. Study protocol for a phase III multi-centre, randomized, open-label, blinded-endpoint trial to evaluate the efficacy and safety of immunoglobulin plus Cyclosporin A in patients with severe Kawasaki disease (KAICA Trial). BMJ Open 2015;5(12):e009562. DOI: 10.1136/bmjopen-2015-009562.
  37. Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Validity assessment of self-reported medication use by comparing to pharmacy insurance claims. BMJ Open 2015;5(11):e009490. DOI: 10.1136/bmjopen-2015-009490.
  38. Iwasa S, Nagashima K, Yamaguchi T, Matsumoto H, Ichikawa Y, Goto A, Yasui H, Kato K, Okita N, Shimada Y, Yamada Y. S-1 and irinotecan with or without bevacizumab versus 5-fluorouracil and leucovorin plus oxaliplatin with or without bevacizumab in metastatic colorectal cancer: a pooled analysis of four phase II studies. Cancer Chemotherapy and Pharmacology 2015;76(3):605–614. DOI: 10.1007/s00280-015-2834-4.
  39. Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Predictive power of a body shape index for development of diabetes, hypertension, and dyslipidemia in Japanese adults: a retrospective cohort study. PLoS ONE 2015;10(6):e0128972. DOI: 10.1371/journal.pone.0128972.
  40. Utsumi H, Honma Y, Nagashima K, Iwasa S, Takashima A, Kato K, Hamaguchi T, Yamada Y, Shimada Y, Kishi Y, Nara S, Esaki M, Shimada K. Bevacizumab and postoperative wound complications in patients with liver metastases of colorectal cancer. Anticancer Research 2015;35(4):2255–2261. URL: http://ar.iiarjournals.org/content/35/4/2255.
  41. Takahashi N, Yamada Y, Furuta K, Nagashima K, Kubo A, Sasaki Y, Shoji H, Honma Y, Iwasa S, Okita N, Takashima A, Kato K, Hamaguchi T, Shimada Y. Association between serum ligands and the skin toxicity of anti-EGFR antibody in metastatic colorectal cancer. Cancer Science 2015;106(5):604–610. DOI: 10.1111/cas.12642.
  42. Nagashima K, Yanai T, Iwasa S, Ohyanagi F, Kasai T, Minato K, Sakai H, Sakamoto C, Takeda K, Harada D, Goto K, Yamamoto N. A double-blind randomized phase II study of olanzapine 10mg versus 5mg for highly emetogenic chemotherapy-induced emesis. Japanese Journal of Clinical Oncology 2015;75(2):229–231. DOI: 10.1093/jjco/hyu191.
  43. Shirakawa T, Kato K, Nagashima K, Nishikawa A, Sawada R, Takahashi N, Shoji H, Sasaki Y, Honma Y, Iwasa S, Takashima A, Okita N, Hamaguchi T, Yamada Y, Shimada Y. A retrospective study of docetaxel or paclitaxel in patients with advanced or recurrent esophageal squamous cell carcinoma who previously received fluoropyrimidine- and platinum-based chemotherapy. Cancer Chemotherapy and Pharmacology 2014;74(6):1207–1215. DOI: 10.1007/s00280-014-2597-3.
  44. Shoji H, Yamada Y, Taniguchi H, Nagashima K, Okita N, Takashima S, Honma Y, Iwasa S, Kato K, Hamaguchi T, Shimada Y. Clinical impact of c-MET expression and genetic mutational status in colorectal cancer patients after liver resection. Cancer Science 2014;105(8):1002–1007. DOI: 10.1111/cas.12453.
  45. Iwasa S, Nakajima TE, Nagashima K, Honma Y, Kato K, Hamaguchi T, Yamada Y, Shimada Y. Lack of association of proteinuria and clinical outcome in patients treated with bevacizumab for metastatic colorectal cancer. Anticancer Research 2013;33(1):309–316. URL: http://ar.iiarjournals.org/content/33/1/309.
  46. Horita Y, Yamada Y, Kato K, Hirashima Y, Akiyoshi K, Nagashima K, Nakajima TE, Hamaguchi T, Shimada Y. Phase II clinical trial of second-line FOLFIRI plus bevacizumab for patients with metastatic colorectal cancer: AVASIRI trial. International Journal of Clinical Oncology 2012;17(6):604–609. DOI: 10.1007/s10147-011-0331-2.
  47. Okita NT, Esaki T, Baba E, Sakai D, Tokunaga S, Takiuchi H, Mizunuma N, Nagashima K, Kato K. A multicenter phase II study of the stop-and-go modified FOLFOX6 with bevacizumab for first-line treatment of patients with metastatic colorectal cancer. Investigational New Drugs 2012;30(5):2026–2031. DOI: 10.1007/s10637-011-9779-1.
  48. Fujie H, Niu K, Ohba M, Tomioka Y, Kitazawa H, Nagashima K, Ohrui T, Numasaki M. A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells. Inflammation 2012;35(3):1119–1131. DOI: 10.1007/s10753-011-9419-0.
  49. Nakajima TE, Yoshida H, Okamoto N, Nagashima K, Taniguchi H, Yamada Y, Shimoda T, Masutomi K. Nucleostemin and TWIST as predictive markers for recurrence after neoadjuvant chemotherapy for esophageal carcinoma. Cancer Science 2012;103(2):233–238. DOI: 10.1111/j.1349-7006.2011.02142.x.
  50. Tanai C, Nakajima TE, Nagashima K, Kato K, Hamaguchi T, Yamada Y, Muro K, Shirao K, Kunitoh H, Matsumura Y, Yamamoto S, Shimada Y. Characteristics and outcomes of patients with advanced gastric cancer who declined to participate in a randomized clinical chemotherapy trial. Journal of Oncology Practice 2011;7(3):148–153. DOI: 10.1200/JOP.2010.000106.
  51. Hashimoto K, Takashima A, Nagashima K, Okazaki S, Nakajima TE, Kato K, Hamaguchi T, Yamada Y, Shimada Y. Progression-free survival in first-line chemotherapy is a prognostic factor in second-line chemotherapy in patients with advanced gastric cancer. Journal of Cancer Research and Clinical Oncology 2010;136(7):1059–1064. DOI: 10.1007/s00432-009-0752-8.

著書 (翻訳書)

  1. 五所正彦(監訳),佐藤泰憲,竹内久朗,長島健悟,中水流嘉臣,平川晃弘,松永信人,山田雅之.生存時間解析入門 原書第2版.東京大学出版会 2014. (Hosmer DW, Lemeshow S, May S. Applied Survival Analysis: Regression Modeling of Time-to-Event Data, 2nd. Editon. Wiley, 2008.) [Web Site]

原著論文 (和文)

  1. 大島新司, 間祐太朗, 長島健悟, 田中享, 佐野元彦, 太田昌一郎, 細谷治, 安野伸浩, 從二和彦. フェンタニル貼付剤の粘着性に関する検討―貼付試験と粘着性による評価―. 日本緩和医療薬学雑誌 2012;5:7–13.

総説・解説

  1. 佐藤泰憲, 長島健悟, 高橋翔. 医学・薬学研究における生存時間データの統計解析. 日本小児アレルギー学会誌 2016;30(5):659–665. DOI: 10.3388/jspaci.30.659.
  2. 佐藤泰憲, 長島健悟, 高橋翔. 医学・薬学研究における統計モデル解析. 日本小児アレルギー学会誌 2016;30(4):580–586. DOI: 10.3388/jspaci.30.580.
  3. 佐藤泰憲, 長島健悟, 高橋翔. 医学・薬学研究における症例数設計. 日本小児アレルギー学会誌 2016;30(2):190–197. DOI: 10.3388/jspaci.30.190.
  4. 佐藤泰憲, 長島健悟, 高橋翔. 医学・薬学データの統計解析I:推定と検定. 日本小児アレルギー学会誌 2015;29(5):718–723. DOI: 10.3388/jspaci.29.718.
  5. 佐藤泰憲, 長島健悟, 高橋翔. 疫学研究の計画:研究デザインとデータ解析. 日本小児アレルギー学会誌 2015;29(3):312–317. DOI: 10.3388/jspaci.29.312.
  6. 佐藤泰憲, 高橋翔, 長島健悟. 臨床試験の計画:試験デザインとデータ解析. 日本小児アレルギー学会誌 2015;29(2):214–221. DOI: 10.3388/jspaci.29.214.
  7. 五所正彦, 長島健悟, 佐藤泰憲. バイオマーカー探索的研究デザイン. 日本臨牀 2012;70(5):874–879.
  8. 佐藤泰憲, 長島健悟, 浜田知久馬. 個別化医療のための研究デザインと統計解析法. 臨床薬理 2010;41(6):291–300. DOI: 10.3999/jscpt.41.291.
  1. 非小細胞肺がんの転移活性を評価し、術後補助化学療法の効果を予測するバイオマーカーの実用化に関する研究. 国立研究開発法人 日本医療研究開発機構:革新的がん医療実用化研究事業. 2017年4月–2020年3月. (研究分担者)
  2. タンパク質・ペプチド修飾解析による早期がん・リスク疾患診断のための血液バイオマーカーの開発. 国立研究開発法人 日本医療研究開発機構:次世代がん医療創生研究事業. 2017年4月–2019年3月. (研究分担者)
  3. 性差に基づく至適薬物療法の検討. 国立研究開発法人 日本医療研究開発機構:女性の健康の包括的支援実用化研究事業—Wise. 2016年11月–2019年3月. (研究分担者)
  4. 膵がん検診の効率化を目指した血液バイオマーカーの実用化研究. 国立研究開発法人 日本医療研究開発機構:革新的がん医療実用化研究事業. 2016年9月–2017年3月. (研究分担者)
  5. レアイベントデータに対する統計的推測と臨床研究への応用. 文部科学省:科学研究費補助金 若手研究(B) 16K16014. 2016年4月–2019年3月. (研究代表者)

講義

単発の講義

Talks

    Statistical Methodology

  1. Noma H, Nagashima K. Asymptotic behaviors of the Mantel–Haenszel estimators and their robust variance estimators when the common effect assumptions are violated. ENAR 2016 Spring Meeting, Mar. 6–9, 2016, JW Marriott Austin, Texas. (Poster) [Abstract]
  2. Noma H, Nagashima K. Asymptotic behaviors of the Mantel–Haenszel estimators under the common effect assumptions violated. Kyoto International Conference on Modern Statistics in the 21st Century, Nov. 17–18, 2014, Kyoto International Conference Center, Kyoto. [Info]
  3. Nagashima K, Sato Y. Information criterion for Firth-type penalized partial likelihood in Cox regression. The 27th International Biometric Conference, Jul. 6–11, 2014, Firenze Fiera, Italy. (Poster) [Abstract]
  4. Nagashima K, Sato Y, Hamada C. A high-speed method for population pharmacokinetic data analysis in genome-wide pharmacogenomic studies. The 26th International Biometric Conference, Aug. 26–31, 2012, Kobe Internatioanl Conference Center Kobe, Japan. (Poster) [Abstract]
  5. Nagashima K, Sato Y, Hamada C. Studentized modified maximum contrast method for unequal sample sizes in pharmacogenomics studies. The 25th International Biometric Conference, Dec. 5-10, 2010, Federal University of Santa Catarina, Florianópolis, SC, Brazil. [Info] [Abstract]
  6. Sato Y, Laird NM, Kato R, Nagashima K, Hamada C, Yoshimura I, Sakamoto H, Yoshida T. Modified maximum contrast method to detect pharmacokinetics-related genes in pharmacogenomics studies. ISCB 28, Aug. 2, 2007, Alexandroupolis, Greece.
  7. Medical Researches

  8. Shoji H, Miyamoto H, Hara H, Takahari D, Machida N, Esaki T, Nagashima K, Aoki K, Honda K, Nagata Y, Miyamoto T, Boku N, Kato K. A phase 1/2 study of ramucirumab plus nivolumab in patients with previously treated advanced gastric adenocarcinoma. ESMO 2017 Congress, Sep. 8–12, 2017, IFEMA - Feria de Madrid, Spain. (Poster)
  9. Sasaki Y, Kato K, Hirano H, Shoji H, Honma Y, Iwasa S, Takashima A, Hamaguchi T, Nagashima K, Boku N. Evaluation of α-1-acid glycoprotein as a prognostic marker and as a predictive biomarker for severe neutropenia induced by docetaxel in esophageal carcinoma patients. AACR Annual Meeting 2017, Apr. 1–5, 2017, Walter E. Washington Convention Center, Washington, D. C. (Poster) [Abstract]
  10. Terazawa T, Iwasa S, Sasaki Y, Okazaki S, Goto M, Kojima Y, Naganuma A, Nagashima K, Hirano H, Honma Y, Takashima A, Kato K, Hamaguchi T. A multicenter phase II study of combination therapy with oral S-1 plus cisplatin in elderly patients with advanced gastric cancer. ASCO 2017 Gastrointestinal Cancers Symposium, Jan. 19–21, 2017, Moscone West Building, San Francisco, CA. (Poster) [Abstract]
  11. Tsushita N, Honma Y, Nagashima K, Miyamoto T, Nakamura S, Umezawa R, Ito Y, Shoji H, Takashima A, Iwasa S, Kato K, Hamaguchi T, Itami J, Boku N. Risk factor analyses of severe cicatricial stricture after chemoradiotherapy for stage II/III (T3) esophageal carcinoma. ASCO 2017 Gastrointestinal Cancers Symposium, Jan. 19–21, 2017, Moscone West Building, San Francisco, CA. (Poster) [Abstract]
  12. Kato K, Kojima T, Ito Y, Igaki H, Daiko H, Onozawa M, Hamamoto Y, Matsushita N, Nagashima K, Katano S. Feasibility study of neo-chemoradiotherapy for stage IB/II/III esophageal squamous cell carcinoma: A 4-year follow up. 2016 the Japanese Society of Medical Oncology Annual Meeting, Jul. 28–30, 2016, Kobe Internatinal Conference Center & Kobe Internatinal Exhibition Hall, Kobe. [Abstract]
  13. Suzuki W, Ohyanagi F, Yanai T, Hashimoto H, Takashima A, Nakao M, Nakayama T, Iwasa S, Nagashima K, Yamamoto N. A double-blind randomized phase II study of 10 versus 5 mg olanzapine for emesis induced by cisplatin-based chemotherapy. 2016 the Japanese Society of Medical Oncology Annual Meeting, Jul. 28–30, 2016, Kobe Internatinal Conference Center & Kobe Internatinal Exhibition Hall, Kobe.
  14. Hashimoto H, Yanai T, Nagashima K, Okita NT, Horinouchi H, Takiguchi T, Ohyanagi F, Nakao M, Takeda K, Nakayama T, Sakai H, Arai T, Minato K, Kogure Y, Harada D, Suzuki K, Boku N, Shimada Y, Iwasa S, Yamamoto N. A double-blind randomized phase II study of 10 versus 5 mg olanzapine for emesis induced by highly emetogenic chemotherapy with cisplatin. 2016 ASCO Annual Meeting, Jun 3–7, 2016, McCormick Place, Chicago, Illinois. (Poster; J Clin Oncol 2016; 34(suppl): abstr 10111) [Abstract] HOT
  15. Ohba A, Takashima A, Nishiuchi T, Honma Y, Iwasa S, Okita N, Kato K, Hamaguchi T, Nagashima K, Boku N. Second-line chemotherapy with paclitaxel for elderly patients with advanced gastric cancer. ASCO 2016 Gastrointestinal Cancers Symposium, Jan. 21–23, 2016, Moscone West Building, San Francisco, CA. (Poster) [Abstract]
  16. Tada K, Kitano S, Shoji H, Nishimura T, Shimada Y, Nagashima K, Yoshitaka Honma Y, Iwasa S, Okita N, Takashima A, Kato K, Yamada Y, Katayama N, Narikazu Boku N, Hamaguchi T, Heike Y. Immune status at pre-treatment impacts on progression-free survival of metastatic colorectal cancer patients treated with first-line chemotherapy. 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015), Nov. 4–8, 2015, Gaylord National Hotel & Convention Center, National Harbor, Maryland. (Poster) [Abstract]
  17. Sasaki Y, Akasu T, Saito N, Kojima H, Matsuda K, Nakamori S, Komori K, Amagai K, Yamaguchi T, Nagashima K, Okita N, Yamada Y. Impact of KRAS/NRAS mutation status on the outcomes of patients with stage III colorectal cancer: Correlative study in NSAS-CC/RC. The 18th ECCO - 40th ESMO European Cancer Congress, Sep. 25–29, 2015, Messe Wien Exhibition & Congress Centre, Vienna, Austria. (Poster) [Abstract]
  18. Shoji H, Heike Y, Tada K, Kitano S, Nishimura T, Shimada Y, Nagashima K, Ito A, Honma Y, Iwasa S, Okita N, Takashima A, Kato K, Yamada Y, Boku N, Hamaguchi T. Association between the peripheral immune status of granulocytic myeloid-derived suppressor cells and progression-free survival chemotherapy. The 18th ECCO - 40th ESMO European Cancer Congress, Sep. 25–29, 2015, Messe Wien Exhibition & Congress Centre, Vienna, Austria. (Poster) [Abstract]
  19. Tada K, Shoji H, Kitano S, Nishimura T, Shimada Y, Nagashima K, Ito A, Honma Y, Iwasa S, Okita M, Takashima A, Kato K, Yamada Y, Katayama N, Boku N, Heike Y, Hamaguchi T. Identification of an immunological prognostic factor for metastatic colorectal cancer patients treated with first-line oxaliplatin-based chemotherapy. The 18th ECCO - 40th ESMO European Cancer Congress, Sep. 25–29, 2015, Messe Wien Exhibition & Congress Centre, Vienna, Austria. (Poster) [Abstract]
  20. Honma Y, Terauchi T, Tateishi U, Kano D, Nagashima K, Okita NT, Takashima A, Iwasa S, Kato K, Hamaguchi T, Shimada Y, Boku N, Yamada Y. Imaging peritoneal metastasis of gastric cancer with PET/CT and the radiotracer 18F-fluorothymidine (18F-FLT): Proof-of-concept study. 2015 ASCO Annual Meeting, May 29–Jun. 2, 2015, McCormick Place, Chicago, Illinois. (Poster discussion session) [Abstract]
  21. Hirashima Y, Hanaoka T, Watanabe K, Nagashima K, Inagaki T, Nishikawa K, Hisamatsu Y, Morinaga R, Otsu S, Kumamoto T, Shirao K. A prospective study to evaluate the usefulness of the clanging tuning fork test and the nerve conduction velocity test for oxaliplatin-induced peripheral neuropathy. ASCO 2015 Gastrointestinal Cancers Symposium, Jan. 15–17, 2015, Moscone West Building, San Francisco, CA. (Poster) [Abstract]
  22. Yuda S, Kato K, Sasaki Y, Takahashi N, Shoji H, Takashima A, Okita NT, Honma Y, Iwasa S, Hamaguchi T, Yamada Y, Nagashima K, Boku N. Risks of severe adverse events of docetaxel, cisplatin, and 5-fluorouracil (DCF) combination chemotherapy of esophageal cancer. ASCO 2015 Gastrointestinal Cancers Symposium, Jan. 15–17, 2015, Moscone West Building, San Francisco, CA. (Poster) [Abstract]
  23. Kubo A, Yamada Y, Takahashi N, Nagashima K, Hashimoto H, Iwasa S, Honma Y, Okita N, Takashima A, Kato K, Hamaguchi T, Hayashi Y, Shimada Y. Serum epiregulin is associated with prognosis and skin toxicity on anti-EGFR antibody treatment in KRAS wild-type mCRC. The 73rd Annual Meeting of the Japanese Cancer Association, Sep. 25–27, 2014, Pacifico Yokohama, Kanagawa. (Poster)
  24. Kubo E, Kato K, Honma Y, Iwasa S, Hamaguchi T, Yamada Y, Shimada Y, Ito Y, Itami J, Nagashima K. Comparison of the long-term toxicities with two different chemoradiotherapy for esophageal squamous cell carcinoma. The 12th Annual Meeting of Japanese Society of Medical Oncology, Jul. 17–19, 2014, Fukuoka.
  25. Takahashi S, Ishiwada N, Hishiki H, Nagasawa K, Chang B, Nagashima K. Serotype distribution and drug resistance of streptococcuspneumoniae isolated from children with community acquired pneumonia in Japan. 13th International Congress on Pediatric Pulmonology, Jun. 26–29, 2014, Bruges, Belgium. (Poster) [Abstract]
  26. Iwasa S, Hamaguchi T, Nagashima K, Goto M, Okazaki S, Sasaki Y, Nagai Y, Asami C, Shimada Y. Multicenter phase II study of combination therapy with oral S-1 plus cisplatin in elderly patients with advanced gastric cancer. ESMO 16th World Congress on Gastrointestinal Cancer, Jun. 25–28, 2014, Barcelona, Spain. (Poster) [Abstract]
  27. Kato K, Hashimoto J, Ito Y, Nagashima K, Kojima T, Daiko H, Akimoto T, Hamamoto Y, Matsushita H, Katano S, Hara H, Tanaka Y, Saito Y, Igaki H. Phase II study of neoadjuvant chemoradiotherapy with cisplatin plus 5-fluorouracil and elective nodal irradiation for stage II/III esophageal squamous cell carcinoma: A 2-year follow up. ASCO 2014 Gastrointestinal Cancers Symposium, Jan. 16–18, 2014, The Moscone West Building, San Francisco, CA. (Poster) [Abstract]
  28. Goto A, Yamada Y, Iwasa S, Nagashima K, Yamaguchi T, Ichikawa Y, Yasui H, Kato K, Okita NT, Shimada Y. S-1 and irinotecan versus 5-fluorouracil and leucovorin plus oxaliplatin with or without bevacizumab in metastatic colorectal cancer: A pooled analysis of 4 phase II studies. The 17th ECCO, 38th ESMO, 32nd ESTRO, European Cancer Congress. Sep. 27–Oct. 1, 2013, Amsterdam. (Poster) [Abstract]
  29. Hirashima Y, Hanaoka T, Watanabe K, Nagashima K, Nishikawa K, Morinaga R, Otsu S, Kumamoto T, Shirao K. A prospective study to evaluate the usefulness of neurological test for oxaliplatin-induced peripheral neuropathy. The 11th Annual Meeting of Japanese Society of Medical Oncology, Aug. 29–31, 2013, Tohoku University Centennial Hall, Sendai, Miyagi.
  30. Kato K, Nakajima T, Ito Y, Katada C, Ishiyama H, Tokunaga S, Tanaka M, Hironaka S, Hashimoto T, Ura T, Kodaira T, Yoshimura K, Nagashima K, Ishikura S. Phase II study of concurrent chemoradiotherapy with elective nodal irradiation for stage II-III esophageal carcinoma, modified RTOG regimen. The 9th Annual Meeting of Japanese Society of Medical Oncology, Jul. 21–23, 2011, Pacifico Yokohama, Yokohama, Kanagawa.
  31. Okita NT, Kato K, Tokunaga S, Esaki T, Baba E, Takiuchi H, Mizunuma N, Kato T, Inaba Y, Kanemitsu Y, Yasui H, Fuse N, Hamaguchi T, Yamada Y, Shimada Y, Nagashima K. Dose Initial tumor size affect bevacizumab efficay in 1st-line FOLFOX treatment for metastatic CRC? The 9th Annual Meeting of the Japanese Society of Medical Oncology, Jul. 21–23, 2011, Pacifico Yokohama, Yokohama, Kanagawa. (Poster)
  32. Hirashima Y, Yamada Y, Tateishi U, Kato K, Miyake M, Horita Y, Akiyoshi K, Nagashima K, Nakajima TE, Hamaguchi T, Shimada Y, Shirao K. New analysis of the hypertension mechanism in bevacizumab-treated patients using 3-Tesla dynamic contrast-enhanced magnetic resonance imaging. ASCO 2011 Gastrointestinal Cancers Symposium, Jan. 20–22, 2011, The Moscone West Building, San Francisco, CA. (Poster) [Abstract]
  33. Akiyoshi K, Yamada Y, Hirashima Y, Horita Y, Kato K, Nagashima K, Nakajima TE, Hamaguchi T, Shimada Y. Phase II trial of the second-line 5-fluorouracil ℓ-leucovorin/irinotecan (FOLFIRI) and bevacizumab for patients with metastatic colorectal cancer: AVASIRI trial. ASCO 2010 Gastrointestinal Cancers Symposium, Jan. 22–24, 2010, The Orlando World Center Marriott, Orlando, Florida. (Poster) [Abstract]
  34. Yoshida H, Okita NT, Esaki T, Baba E, Sakai D, Tokunaga S, Takiuchi H, Mizunuma N, Nagashima K, Kato K. Phase II study of the "stop and go" modified FOLFOX6 regimen with bevacizumab for first-line patients with metastatic colorectal cancer. ASCO 2010 Gastrointestinal Cancers Symposium, Jan. 22–24, 2010, The Orlando World Center Marriott, Orlando, Florida. (Poster) [Abstract]

国内学会発表

    統計手法

  1. 佐藤泰憲, 長島健悟. 個別化医療のための研究デザイン ~Enrichment Designを中心に~. 日本計算機統計学会 第27回大会, 2013年5月16日, 弘前大学創立50周年記念会館.
  2. 長島健悟. ゲノム網羅的解析における薬物動態関連遺伝子検出のためのスチューデント化修正最大対比法の提案. 統計数理研究所リスク解析戦略研究センター研究会, 2010年3月26日, 癌研究所. [Slide]
  3. 長島健悟, 佐藤泰憲, Laird NM. ゲノムワイド関連解析における薬物動態関連遺伝子同定のための新しいスクリーニング法. SASユーザー総会, 2009年7月30日, タワーホール船堀. [Report]
  4. 長島健悟, 堀尾浩史, 浜田知久馬. HWD 下での Fisher の正確検定の性能比較. 統計関連学会連合大会, 2007年9月7日, 神戸大学.
  5. 統計ソフトウェア

  6. 長島健悟. Rパッケージの開発・登録とメンテナンス. 2010年度 統計数理研究所共同研究集会「データ解析環境 R の整備と利用」, 2010年11月25日–27日, 統計数理研究所. [Slide]
  7. 長島健悟, 佐藤泰憲. Kaplan-Meier プロットに付加情報を追加するマクロの作成. SAS ユーザー総会, 2010年7月26日–27日, タワーホール船堀. [Report] [Slide]
  8. 共同研究 (臨床試験・疫学・基礎)

  9. 中山季昭, 酒井洋, 矢内貴子, 橋本浩伸, 後藤悌, 瀧口友美, 大柳文義, 中尾將彦, 武田晃司, 新井隆広, 湊浩一, 鈴木賢一, 岩佐悟, 長島健悟, 山本昇. 制吐作用を目的としたオランザピン10mgと5mgの有効性と安全性を評価する用量設定試験. 第54回日本癌治療学会学術集会, 2016年10月20日–10月22日, パシフィコ横浜, 横浜.
  10. 中尾將彦, 吉田徹也, 矢内貴子, 橋本浩伸, 本永正矩, 瀧口友美, 大柳文義, 中山季昭, 齊藤こずも, 藤田行代志, 湊浩一, 鈴木賢一, 寺門浩之, 岩佐悟, 長島健悟, 山本昇. 高度催吐性化学療法施行時の悪心・嘔吐の予防に対するオランザピン10mgと5mgの有効性と安全性を評価する用量設定第2相試験. 第26回 日本医療薬学会年会, 2016年9月17日–9月19日, 国立京都国際会館・グランドプリンスホテル京都, 京都.
  11. 岩佐悟, 濱口哲弥, 後藤昌弘, 岡崎俊介, 笹木有佑, 長井祐志, 浅見千佳, 長島健悟, 島田安博. 高齢者切除不能の進行・再発胃癌を対象としたS-1/CDDP療法の多施設共同第Ⅱ相試験. 第52回 日本癌治療学会学術集会, 2014年8月28日–8月30日, パシフィコ横浜, 横浜.
  12. 岩佐悟, 濱口哲弥, 後藤昌弘, 富所隆, 笹木有佑, 長井祐志, 浅見千佳, 長島健悟, 島田安博. 高齢者切除不能進行・再発胃癌を対象としたS-1/CDDP療法の多施設共同第II相試験. 第51回 日本癌治療学会学術集会, 2013年10月24日–10月26日, 国立京都国際会館・グランドプリンスホテル京都, 京都.
  13. 山口達郎, 山田康秀, 岩佐悟, 松本寛, 市川靖史, 後藤歩, 安井久晃, 加藤健, 沖田南都子, 長島健悟, 島田安博. 進行・再発大腸がんのS-1/イリノテカン±ベバシズマブ療法 第II相試験の統合解析. 第51回 日本癌治療学会学術集会, 2013年10月24日–10月26日, 国立京都国際会館・グランドプリンスホテル京都, 京都.
  14. 竜野真維, 加藤健, 本間義崇, 岩佐悟, 濱口哲弥, 山田康秀, 島田安博, 馬屋原博, 伊藤芳紀, 伊丹純, 長島健悟. 臨床病期 II/III 期食道がんに対する化学放射線療法における追加化学療法の意義について. 第66回日本食道学会学術集会, 2012年6月21日–6月21日, 軽井沢プリンスホテルウエスト, 軽井沢.
  15. 中谷祥恵, 長島健悟, 増井彩乃, 川口光朗, 又平芳春, 藤堂浩明, 杉林堅次, 古旗賢二, 和田政裕. N-アセチルグルコサミンの摂取は健常人の季節変動に伴う肌水分量の低下を抑制する. 第25回キチン・キトサンシンポジウム, 2011年8月30日–31日, 奈良県新公会堂.
  16. 徳永伸也, 沖田南都子, 江崎泰斗, 馬場英司, 坂井大介, 瀧内比呂也, 水沼信之, 長島健悟, 濱口哲弥, 加藤健. 切除不能進行・再発大腸がんに対する mFOLFOX6+BV stop and go 臨床第II相試験. 第8回日本臨床腫瘍学会学術集会, 2010年3月18日–3月19日, 東京ビッグサイト, 有明.
  17. 堀田洋介, 山田康秀, 加藤健, 平島詳典, 秋吉宏平, 長島健悟, 中島貴子, 濱口哲弥, 島田安博. 切除不能大腸癌二次治療例に対する FOLFIRI + Bevacizumab 療法の臨床第 2 相試験 (AVASIRI study). 第8回日本臨床腫瘍学会学術集会, 2010年3月18日–3月19日, 東京ビッグサイト, 有明. (Poster)
  18. 佐藤真樹, 上田秀雄, 長島健悟, 木村聡一郎, 寺尾哲, 青木富雄, 森本雍憲. 悪性腫瘍患者における感染性と非感染性発熱の識別モデルに関する検討. 日本薬学会 第129年会, 2009年3月26日–28日, グランドプリンスホテル京都, 京都市, 京都. (Poster)
  19. 橋本堅治, 高島淳生, 長島健悟, 佐藤宏征, 岡崎俊介, 中島貴子, 加藤健, 濱口哲哉, 山田康秀, 島田安博. 切除不能・再発進行胃がんに対する二次化学療法における予後因子の検討. 第46回 日本癌治療学会総会, 2008年10月30日–11月1日, 名古屋国際会議場.

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